Lloyd lab research article recognized

The Environmental Mutagenesis and Genomics Society has selected an article written by investigators in the laboratory of R. Stephen Lloyd as the Editor’s Choice, to be highlighted on the cover of an upcoming edition of the society’s journal, Environmental and Molecular Mutagenesis. The article, “Error-Prone Replication Bypass of the Imidazole Ring-Opened Formamidopyrimidine Deoxyguanosine Adduct”, was written by Yan Sha, Irina G. Minko, Chanchal K. Malik, Carmelo J. Rizzo, and R. Stephen Lloyd.

Damage to DNA caused by reactive oxygen species promotes mutations, cancer and aging. Reactive oxygen species can be generated as a consequence of chronic inflammation, exposure to ionizing radiation, chemotherapy and other cancer-causing chemicals. In the April 2017 issue of Environmental and Molecular Mutagenesis, Yan Sha and coworkers at the Oregon Institute of Occupational Health Sciences and Vanderbilt University discovered a heretofore unknown mechanism of mutation that occurs in cells. Given the importance of understanding the mutagenic potential of DNA damage generated by the reactive oxygen species and the exacting nature of the experiments reported, the Environmental Mutagenesis and Genomics Society selected this article as the “Editor’s Choice” for the April issue of Environmental and Molecular Mutagenesis.